Neuropathology (the Brain Bank for Aging Research)

Members

Theme Leader:
Yuko Saito, M.D., Ph.D.

Specially Appointed Researcher (full time) Secretary General of BBAR
Shigeo Murayama, M.D., Ph.D.

Researcher:
Akira Arakawa M.D.
Manato Hara M.D.

Visiting Researcher
Tomoyasu Matsubara M.D. Ph.D.
Akiko Uchino M.D. Ph.D.
Maho Morishima, Ph.D.

Technician
Hiroshi Koga
Natsuki Kawada

Manager
Manami Itagaki

Keywords

neurology, neuropathology, brain bank, MCI, - amyloid, t, -synuclein, TDP43, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, argyrophilic grain disease, progressive supranuclear palsy, corticobasal degeneration, amyotrophic lateral sclerosis, fronto- temporal lobar degeneration, Prion disease, NOTCH2-NLC related NIID

Major Research Titles

  1. Brain Bank for Aging Research Project.
  2. Dynamic, molecular and statistic neuropathology.

Profile

Our group plays an important role interfacing the clinical and basic research in the Tokyo Metropolitan Institute of Geriatrics and Gerontology (TMIGG). We have been extensively carrying out a brain bank project for aging and dementia and constructing geriatric neuropathology data set, consisting of summary of clinical records, in vivo neuroimaging data and neuropathological findings of postmortem brain.
Our research themes include prospective and retrospective studies of cognitive disorder, mechanistic approaches to Alzheimer disease, Lewy body disease, senile tauopathy and TDP 43 proteinopathy, in collaboration with distinguished worldwide neuroscientists. Our group is a pioneer in establishing an essential infrastructure for human brain research in Japan.

References (2024 only)

  1. Funakawa K, Kurihara M, Takahashi K, Higashihara M, Hara M, Mitsutake A, Ishiura H, Tokumaru AM, Sonoo M, Murayama S, Saito Y, Iwata A: Proximal sensory neuropathy and cerebellar ataxia as presenting symptoms of NOTCH2NLC-related neuronal intranuclear inclusion disease. J Neurol Sci 2024, 458:122915.
  2. Kikuchi M, Miyashita A, Hara N, Kasuga K, Saito Y, Murayama S, Kakita A, Akatsu H, Ozaki K, Niida S, Kuwano R, Iwatsubo T, Nakaya A, Ikeuchi T, Alzheimer's Disease Neuroimaging I, Japanese Alzheimer's Disease Neuroimaging I: Polygenic effects on the risk of Alzheimer's disease in the Japanese population. Alzheimers Res Ther 2024, 16:45.
  3. Kurihara M, Matsubara T, Morimoto S, Arakawa A, Ohse K, Kanemaru K, Iwata A, Murayama S, Saito Y: Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Abeta42 in Alzheimer's disease and other neurodegenerative diseases. Acta Neuropathologica Communications 2024, 12:48.
  4. Matsubara T, Ishii K, Saito Y, Tokumaru A, Arakawa A, Hara M, Kurihara M, Sengoku R, Kanemaru K, Iwata A, Arai T, Miyashita A, Ikeuchi T, Hasegawa M, Murayama S, Yuko Saito Y: Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy. Acta Neuropath Commu 2024; 12: 98 https://doi.org/10.1186/s40478-024-01815.
  5. Arseni D, Nonaka T, Jacobsen M, Murzin A, Cracco L, Peak-Chew S, Garringer H, Kawakami I, Suzuki H, Onaya M, Saito Y, Murayama S, Geula C, Vidal R, Newell K, Mesulam M, Ghetti B, Hasegawa M, Ryskeldi-Falcon B: Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C. Nature on line 11 September 2024
  6. Kurihara M, Arakawa A, Tokumaru A, Matsubara T, Eguchi H, Shimo Y, Hasegawa M, Kanemaru K, Takeda K, Iwata A, Murayama S, Saito Y: Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation. eNeurological Sci in press
  7. Kashiwagi M, Beck G, Kanuka M, Arai Y, 2, Tanaka K, Tatsuzawa C, Koga Y, Saito Y, Takagi M, Oishi Y, 5 4, Sakaguchi M, Baba K, Ikuno M, Yamakado H, Takahashi R, Yanagisawa M, Murayama S, Sakurai T, Sakai K, Nakagawa Y, Watanabe M, Mochizuki H, Yu Hayashi* 1, 2: A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease. Cell in press
  8. Burré J, Edwards R, Halliday G, Lang A 4 5, Lashuel H, Melki R, Murayama S, Outeiro T, Papa S 12, Stefanis L, Woerman A, Surmeier D, Kalia L, Takahashi R; MDS Scientific Issues Committee: Research priorities on the role of alpha-synuclein in Parkinson's disease pathogenesis. Movement Disorder in press.
  9. Tezuka T, Ishiguro M, Taniguchi D, Osogaguchi E, Shiba-Fukushima K, Ogata J, Ishii R, Ikeda A, Li Y, Yoshino H, Matsui T, Kaida K, Funayama M, Nishioka K, Kumazawa F, Matsubara T, Tsuda H, Saito Y, Murayama S, Imai Y, Hattori N: Clinical characteristics and pathophysiological properties of newly discovered LRRK2 variants associated with Parkinson's disease. Neurobiol Dis in press.
  10. Miyamoto E, Hayashi H, Murayama S, Yanagisawa K, Sato T, Matsubara T: Prevention of amyloid β fibril deposition on the synaptic membrane in the precuneus by ganglioside nanocluster-targeting inhibitors. RSC Chem Biol 2024; 5: 459-466
  11. Tomenaga T, Minatani S, Namba H, Takeda A, Yoshizaki T, Kawabe J, Keyoumu N, Morino H, Higuchi M, Matsubara T, Hatsuta H, Hasegawa M, Murayama S, Itoh Y: An autopsy case of type A FTLD-TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently. Neuropathology in press
  12. Arakawa A, Goto R, Higashihara M, Hiroyoshi Y, Shioya A, Hara M, Orita M, Matsubara T, Sengoku R, Kameyama M, Tokumaru A, Hasegawa M, Toda T, Iwata A, Murayama S, Saito Y: Clinicopathological study of dementia with grains presenting with parkinsonism compared with a typical case. Neuropathology in press
  13. Uchino A, Saito Y, Tokuda S, Yagishita S, Murayama S, Hasegawa K: An autopsy case of MV 2K + C subtype of Creutzfeldt-Jakob disease. Neuropathology 2024; 44: 304-313
  14. Funakawa K, Kurihara M, Takahashi K, Higashihara M, Hara M, Mitsutake A, Ishiura H, Tokumaru A, Sonoo M, Murayama S, Saito Y, Iwata A: Proximal sensory neuropathy and cerebellar ataxia as presenting symptoms of NOTCH2NLC-related neuronal intranuclear inclusion disease. J Neurol Sc 2024; Epub 2024 Feb 2.
  15. Ikeda A, Meng H, Taniguchi D, Mio M, Funayama M, Nishioka K, Yoshida M, Li Y, Yoshino H, Inoshita T, Shiba-Fukushima K, Okubo Y, Sakurai T, Amo T, Aiba I, Saito Yu , Saito Y, Murayama S, Atsuta N, Nakamura R, Tohnai G, Izumi Y, Morita M, Tamura A, Kano O, Oda M, Kuwabara S, Yamashita T, Sone J, Kaji R, Sobue G, Imai Y, Hattori N: CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca(2+) homeostasis. PNAS Nexus 2024; 3: 319