SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians)

Members

Leader :
Takumi Hirata, M.D., Ph.D.（Health Services Research）
Members :
Yukie Masui, Ph.D., Yuko Yoshida, Ph.D.（Health Services Research）
Kae Ito, M.D., Ph.D., Mayuko Ono, Ph.D.（Social Inclusion Studies）
Hiroki Inagaki, Ph.D.（Dementia and Mental Health Research）
Yuri Miura, Ph.D., Hiroki Tsumoto, Ph.D., Keitaro Umezawa, Ph.D., Kyojiro Kawakami, Ph.D.（Proteome Research）

Keywords

    Healthy longevity; Longitudinal study; People aged 80+; Centenarian; Proteome, Genomic epidemiology; Arteriosclerosis; Aging-related diseases; Oral diseases; Oral function; Nutrition; Cognitive function; Psychological well-being; History of life; Leisure activities; Personality; Psychological strategies of adaptation

    Major Research Titles

    1. Aging-related changes in health status among oldest-old individuals
    2. Influence of psychological strategies of adaptation on decline of cognitive function and psychological well-being
    3. Genetic factors associated with aging-related diseases and healthy longevity
    4. Effects of oral function on nutrition intake and healthy aging

    Profile

    The SONIC study aims to identify aging-related changes in functional characteristics and to examine factors associated with healthy longevity among community-dwelling oldest-old adults.
    The SONIC study has several strengths:
    1) a comprehensive interdisciplinary study including variables regarding medical, biological, sociological, psychological, physical, and dental domains;
    2) a design with sequential comparison of different age cohorts, such as ages 70, 80, 90, and 100 years (narrow age cohort study);
    3) a community-based study conducted in two large geographical regions (Tokyo and Hyogo) and two subregions (an urban area and a rural area) to examine the effects of environment and lifestyle on healthy longevity.
    Each age cohort is followed every 3 years except for the centenarians. The baseline surveys for the 70-year-old cohort, the 80-year-old cohort, and the 90-year-old cohort were completed in 2010, 2011, and 2012, respectively. A follow-up survey has been conducted for each age cohort since 2013. By 2024, the 70-year-old cohort, the 80-year-old cohort and the 90-year-old cohort had completed five follow-up surveys.

    References

    1. Kamide K, Ikebe K, Masui Y, Nakagawa T, Kabayama M, Akasaka H, Mameno T, Murotani Y, Ogawa M, Yasumoto S, Yamamoto K, Hirata T, Arai Y, Gondo Y; SONIC study group. Multidimensional insights about healthy aging from the cohort study for community-dwelling older adults: The SONIC study. Geriatr Gerontol Int 2025; 25: 346-355.
    2. Yoshida Y, Ishizaki T, Masui Y, Miura Y, Matsumoto K, Nakagawa T, Inagaki H, Ito K, Arai Y, Kabayama M, Kamide K, Rakugi H, Ikebe K, Gondo Y. Effects of multimorbidity and polypharmacy on physical function in community-dwelling older adults: a 3-year prospective cohort study from the SONIC. Arch Gerontol Geriatr 2024; 126: 105521.
    3. Masui Y, Nakagawa T, Yasumoto S, Ogawa M, Ishioka Y, Kasuga A, Hori N, Inagaki H, Yoshida Y, Ito K, Takayama M, Arai Y, Ikebe K, Kamide K, Ishizaki T, Gondo Y. Development in gerotranscendence in community-dwelling older adults in Japan: a longitudinal study over a nine-year period. J Adult Dev 2024 (Published Online, doi: 10.1007/s10804-024-09488-5)
    4. Ishizaki T, Masui Y, Hori N, Yano S, Ono K, Mitsutake S. Examining the cross-validity of 12 frailty-related items within the Health Assessment Questionnaire for Older Adults: Insights from annual health checkups in Japan. Geriatr Gerontol Int 2024; 24: 647-649.
    5. Yoshida Y, Ishizaki T, Masui Y, Hori N, Inagaki H, Ito K, Ogawa M, Yasumoto S, Arai Y, Kamide K, Ikebe K, Gondo Y. Effect of number of medications on the risk of falls among community-dwelling older adults: A 3-year follow-up of the SONIC study. Geriatr Gerontol Int 2024; 24: 306-310.
    6. Hori N, Ishizaki T, Masui Y, Yoshida Y, Inagaki H, Ito K, Ishioka YL, Nakagawa T, Ogawa M, Kabayama M, Kamide K, Ikebe K, Arai Y, Gondo Y. Criterion validity of the health assessment questionnaire for the national screening program for older adults in Japan: The SONIC study. Geriatr Gerontol Int 2023; 23: 437-443.
    7. Miura Y, Tsumoto H, Masui Y, Inagaki H, Ogawa M, Ideno Y, Kawakami K, Umezawa K, Kabayama M, Akagi Y, Akasaka H, Yamamoto K, Rakugi H, Ishizaki T, Arai Y, Ikebe K, Kamide K, Gondo Y, Endo T. A characteristic N-glycopeptide signature associated with diabetic cognitive impairment identified in a longitudinal cohort study. Biochim Biophys Acta Gen Subj 2023; 1867: 130316.
    8. Ishizaki T, Masui Y, Nakagawa T, Yoshida Y, Ishioka YL, Hori N, Inagaki H, Ito K, Ogawa M, Kabayama M, Kamide K, Ikebe K, Arai Y, Gondo Y. Construct validity of a new health assessment questionnaire for the national screening program of older adults in Japan: The SONIC Study. Int J Environ Res Public Health 2022; 19: 10330.
    9. Yoshida Y, Ishizaki T, Masui Y, Arai Y, Inagaki H, Ogawa M, Yasumoto S, Iwasa H, Kamide K, Rakugi H, Ikebe K, Gondo Y. Association of personality traits with polypharmacy among community-dwelling older adults in Japan: a cross-sectional analysis of data from the SONIC study. BMC Geriatr 2022; 22: 372.
    10. Ito K, Okamura T, Awata S, Gondo Y, Masui Y, Inagaki H, Kamide K, Ikebe K, Arai Y, Ishizaki T. Factors associated with psychological well-being among nonagenarians: Well-being in the era of 100 years of life. Geriatr Gerontol Int 2022; 22: 364-366.
    11. Miura Y, Hashii N, Tsumoto H, Takakura D, Ohta Y, Abe Y, Arai Y, Kawasaki N, Hirose N, Endo T, on behalf of SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians): Change in N-glycosylation of plasma proteins in Japanese semisupercentenarians. PLoS One 2015; 10: e0142645.
    12. Akema S, Mameno T, Nakagawa T, Inagaki H, Hatta K, Murotani Y, Tsujioka Y, Hagino H, Higashi K, Takahashi T, Wada M, Gondo Y, Kamide K, Kabayama M, Ishizaki T, Masui Y, Ogata S, Ikebe K. Masticatory performance indicates the development of psychological frailty: A 6-year prospective cohort study by the SONIC study group. J Prosthodont Res 2025 (Published Online, doi: 10.2186/jpr.JPR_D_23_00282)
    13. Mameno T, Moynihan P, Nakagawa T, Inagaki H, Akema S, Murotani Y, Takeuchi S, Kimura A, Okada Y, Tsujioka Y, Higashi K, Hagino H, Mihara Y, Kosaka T, Takahashi T, Wada M, Gondo Y, Kamide K, Akasaka H, Kabayama M, Ishizaki T, Masui Y, Ikebe K. Exploring the association between number of teeth, food intake, and cognitive function: A 9-year longitudinal study. J Dent 2024; 145: 104991.
    14. Akema S, Mameno T, Nakagawa T, Inagaki H, Fukutake M, Hatta K, Murotani Y, Tsujioka Y, Hagino H, Higashi K, Takahashi T, Wada M, Maeda Y, Gondo Y, Kamide K, Kabayama M, Ishizaki T, Masui Y, Ogata S, Ikebe K. Relationship between occlusal force and psychological frailty in Japanese community-dwelling older adults: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. J Am Geriatr Soc 2023; 71: 1819-1828.
    15. Ishioka YL, Masui Y, Nakagawa T, Ogawa M, Inagaki H, Yasumoto S, Ikebe K, Kamide K, Arai Y, Ishizaki T, Gondo Y. Early- to late-life environmental factors and late-life global cognition in septuagenarian and octogenarians: The SONIC study. Acta Psychol (Amst) 2023; 233: 103844.
    16. Klinpudtan N, Allsopp RC, Kabayama M, Godai K, Gondo Y, Masui Y, Akagi Y, Srithumsuk W, Sugimoto K, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Ikebe K, Yasumoto S, Ogawa M, Ishizaki T, Arai Y, Rakugi H, Chen R, Willcox BJ, Willcox DC, Kamide K. The association between longevity-associated FOXO3 allele and heart disease in septuagenarians and octogenarians: The SONIC Study. J Gerontol A Biol Sci Med Sci 2022; 77: 1542-1548.
    17. Akagi Y, Kabayama M, Gondo Y, Masui Y, Yasumoto S, Klinpudtan N, Srithumsuk W, Godai K, Ikebe K, Akasaka H, Yokoyama S, Nozato Y, Takami Y, Takeya Y, Yamamoto K, Sugimoto K, Arai Y, Inagaki H, Ishizaki T, Rakugi H, Kamide K. Alcohol drinking patterns have a positive association with cognitive function among older people: a cross-sectional study. BMC Geriatr 2022; 22: 158.
    18. Matsumoto K, Gondo Y, Masui Y, Yasumoto S, Yoshida Y, Ikebe K, Arai Y, Kabayama M, Kamide K, Akasaka H, Ishizaki T. Physical performance reference values for Japanese oldest old: a SONIC study. BMC Geriatr 2022; 22: 748.